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Inquiry should be made regarding a history of kidney stone , since a patient with gout and kidney stones will likely require faster and more aggressive lowering of uric acid (see below) than one without stones, to try and prevent recurrent stone formation

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Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Otmani S, Demazieres A, Staner C, et al

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